![]() ![]() small tidal volumes (6 ml/kg) with rapid ventilatory rates, reduce mortality in acute respiratory distress syndrome (ARDS) patients. One of the most important developments related to mechanical ventilation is the recognition that mechanical ventilation can induce lung injury and that protective ventilation, i.e. It attenuates hypercapnia and respiratory acidosis in a lung injury pig model. ConclusionsĬoaxial double-lumen tube ventilation is an effective adjunct to reduce technical dead space. Partial tube obstruction due to secretions was not observed during the experiments. Tracheal pressure was monitored continuously and no difference between single- or double-lumen ventilation was noted at corresponding levels of ventilation. ![]() At 6 ml/kg, pH increased from 7.17 (95% CI 7.09–7.24) with a standard endotracheal tube to 7.27 (95% CI 7.21–7.32) with double-lumen ventilation. This corresponds to a reduction in carbon dioxide levels by 25%. With a tidal volume of 6 ml/kg, PaCO 2 was reduced from 10.9 kPa (95% CI 9.0–12.9) with a standard endotracheal tube to 8.2 kPa (95% CI 7.0–9.4) with double-lumen ventilation. ![]() Measurements of ventilatory and circulatory parameters were obtained after steady state at each experimental stage. ![]() Tidal volumes of 6, 8 and 10 ml/kg body weight with a set respiratory rate of 20 breaths per minute were used in a random order with both double-lumen ventilation and standard endotracheal tube ventilation. DesignĮxperimental study in a pig model of lung lavage induced acute lung injury. Evaluation of ventilatory and circulatory effects with coaxial double-lumen tube ventilation for dead-space reduction as compared with standard endotracheal tube ventilation. ![]()
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